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白琳

白琳

姓名:白琳

职称/职务:副研究员/转化医学中心主任

学科:细胞生物学

联系方式:bailin49@163.com

导师风采链接:http://pumc.teacher.360eol.com/teacherBasic/preview?teacherType=&teacherId=4278

  • 简历介绍
  • 研究领域
  • 社会任职
  • 获奖及荣誉
  • 承担科研项目情况
  • 代表论著

  白琳,女,博士,副研究员,硕士生导师。1984年01月出生于山西省。2002年-2006年就读于北京师范大学,获理学学士学位。2006年-2011年就读于北京师范大学细胞生物学专业,获得理学博士学位。主要从事干细胞治疗相关研究,研究方向为:(1)干细胞治疗帕金森动物模型的有效性和安全性评价。(2)干细胞衰老机理研究。重要代表性成果以第一作者发表于Cell Research,Cell Death & Disease, Scientific Reports, Experimental Cell Research,and Journal of Cellular Biochemistry等SCI期刊。

  细胞生物学、比较医学、实验动物学。

  担任《中国实验动物学报》和《中国比较医学杂志》通讯编委。
  担任中国老年学和老年医学学会老年病分会衰老基础医学专家委员会委员。

  承担多项研究项目,包括国家自然科学基金面上项目、国家自然基金青年项目、北京市自然科学基金、教育部新教师基金、协和青年等。

1.Lin Bai*, Guiying Shi, Yuanwu Ma, Li Zhang, Feifei Guan, Xu Zhang, Yanfeng Xu, Houzao Chen and Lianfeng Zhang: Paraoxonase 1 knockout rats have impaired T cell development at the CD4/CD8 double-negative to double-positive transition stage. Scientific Reports 8: 14457 (2018)

2.Li Q*, Bai L*, Shi G, Zhang L, Dai Y, Liu P, Cong YS, Wang M: Ptrf transgenic mice exhibit obesity and fatty liver. Clinical and experimental pharmacology & physiology 2018.

3.Ma Y*, Yu L, Zhang X, Xin C, Huang S, Bai L, Chen W, Gao R, Li J, Pan S, Qi X, Huang X, Zhang L: Highly efficient and precise base editing by engineered dCas9-guide tRNA adenosine deaminase in rats. Cell Discov, 2018 Jul 17.

4.Ma Y*, Yu L, Pan S, Gao S, Chen W, Zhang X, Dong W, Li J, Zhou R, Huang L, Han Y, Bai L, Zhang L, Zhang L. CRISPR/Cas9-mediated targeting of the Rosa26 locus produces Cre reporter rat strains for monitoring Cre-loxP-mediated lineage tracing. FEBS J. 2017 Oct;284(19):3262-3277.

5.Bai L*, Shi G, Yang Y, Chen W, Zhang L: Anti-Aging Effect of Siraitia grosuenoriiby Enhancement of Hematopoietic Stem Cell Function. Am J Chin Med 2016:1-13.

6.Bai L*, Shi G, Zhang L, Guan F, Ma Y, Li Q, Cong YS, Zhang L: Cav-1 deletion impaired hematopoietic stem cell function. Cell Death Dis 2014, 5:e1140.

7.Ma Y*, Zhang X, Shen B, Lu Y, Chen W, Ma J, Bai L, Huang X, Zhang L: Generating rats with conditional alleles using CRISPR/Cas9. Cell Res 2014, 24(1):122-125.

8.Li Q*, Bai L*, Liu N, Wang M, Liu JP, Liu P, Cong YS: Increased polymerase I and transcript release factor (Cavin-1) expression attenuates platelet-derived growth factor receptor signalling in senescent human fibroblasts. Clin Exp Pharmacol Physiol 2014, 41(3):169-173.

9.Yang Y*, Ma J, Xiu J, Bai L, Guan F, Zhang L, Liu J: Deferoxamine compensates for decreases in B cell counts and reduces mortality in enterovirus 71-infected mice. Mar Drugs 2014, 12(7):4086-4095.

10.Ma Y*, Ma J, Zhang X, Chen W, Yu L, Lu Y, Bai L, Shen B, Huang X, Zhang L: Generation of eGFP and Cre knockin rats by CRISPR/Cas9. FEBS J 2014, 281(17):3779-3790.

11.Bai L*, Shi G, Zhang X, Dong W, Zhang L: Transgenic expression of BRCA1 disturbs hematopoietic stem and progenitor cells quiescence and function. Exp Cell Res 2013, 319(17):2739-2746.

12.Gao K*, Li X, Zhang L, Bai L, Dong W, Shi G, Xia X, Wu L: Transgenic expression of IL-33 activates CD8(+) T cells and NK cells and inhibits tumor growth and metastasis in mice. Cancer Lett 2013, 335(2):463-471.

13.Bai L*, Deng X, Li Q, Wang M, An W, Deli A, Gao Z, Xie Y, Dai Y, Cong YS: Down-regulation of the cavin family proteins in breast cancer. J Cell Biochem 2012, 113(1):322-328.

14.Zhu B*, Deng X, Sun Y, Bai L, Xiahou Z, Cong Y, Xu X: Nampt is involved in DNA double-strand break repair. Chin J Cancer 2012, 31(8):392-398.

15.Bai L*, Deng X, Li J, Wang M, Li Q, An W, A D, Cong YS: Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Cell Res 2011, 21(7):1088-1101.

16.Yang K*, Zheng D, Deng X, Bai L, Xu Y, Cong YS: Lysophosphatidic acid activates telomerase in ovarian cancer cells through hypoxia-inducible factor-1alpha and the PI3K pathway. J Cell Biochem 2008, 105(5):1194-1201.