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Diverse biological characteristics and varied virulence of H7N9 from Wave 5.

Bao L1, Bi Y2,3, Wong G2,4, Qi W5, Li F1, Lv Q1, Wang L3, Liu F3, Yang Y2, Zhang C3, Liu WJ6, Quan C6, Jia W5, Liu Y2, Liu W3, Liao M5, Gao GF2,3,6, Qin C1.

Author information

1
a Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical Collage (PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health , Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious , Beijing , People's Republic of China.
2
b Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease , Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital , People's Republic of China.
3
c CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology , Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences , Beijing , People's Republic of China.
4
d Département de microbiologie-infectiologie et d'immunologie , Université Laval , Québec City , Canada.
5
e National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, College of Veterinary Medicine , South China Agricultural University , Guangzhou , People's Republic of China.
6
f National Institute for Viral Disease Control and Prevention , Chinese Center for Disease Control and Prevention (China CDC) , Beijing , People's Republic of China.

Abstract

There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic overall, we characterized the receptor binding and experimentally infected ferrets with highly pathogenic (HP)- and low pathogenic (LP)-H7N9 isolates selected from Wave 5, and compared their pathogenicity and transmissibility with a Wave 1 isolate from 2013. Studies show that A/Anhui/1/2013 (LP) and A/Chicken/Heyuan/16876/2016 (HP) were highly virulent in ferrets, A/Guangdong/Th008/2017 (HP) and A/Chicken/Huizhou/HZ-3/2017 (HP) had moderate virulence and A/Shenzhen/Th001/2016 (LP) was of low virulence in ferrets. Transmission was observed only in ferrets infected with A/Anhui/1/2013 and A/Chicken/Heyuan/16876/2016, consistent with the idea that sicker ferrets had a higher probability to transmit virus to naive animals. Given the Varied virulence and transmissibility observed in circulating H7N9 viruses from Wave 5, we conclude that the current public health risk of H7N9 has not substantially increased compared to 2013 and the circulating viruses are quite diverse.

KEYWORDS:

H7N9; ferret; influenza; pathogenicity; receptor; transmissibility


原文链接:https://www.ncbi.nlm.nih.gov/pubmed/30866763