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于海生

于海生

姓名:于海生

学科:病毒感染与免疫

电话:010-67779622

邮件:yuhaisheng_ibp@hotmail.com

地址:北京市朝阳区潘家园南里5号院科研楼1层

  • 简历介绍
  • 研究领域
  • 社会任职
  • 获奖及荣誉
  • 承担科研项目情况
  • 代表论著

  于海生,男,博士。 2003年和2006年在西北农林科技大学,分别获得学士和硕士学位,2016年获中国科学院大学博士学位。2006年-2018年,在中国科学院生物物理研究所工作,任助理研究员和副研究员;2015-2016年在美国北卡罗来纳大学教堂山分校的苏立山教授实验室访问交流;2018年至今为中国医学科学院医学实验动物研究所副研究员。

  利用免疫系统人源化的小鼠模型,研究病毒(HIV, EBV)感染的致病机理及其治疗的策略;
  构建具有免疫系统人源化的小鼠肿瘤模型及药物评价;
  研究树突状细胞亚群及其在病毒感染中的作用。

  “十一五”国家科技重大专项平台项目:建立重大传染病研究的人源化小鼠平台 骨干 中科院知识创新工程重要方向项目:
  构建慢性肝炎病毒感染的人源化小鼠模型 参与 “十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专  项:成人艾滋病适宜治疗策略研究与应用 骨干

基于HIV感染人源化小鼠模型:

1.Yu H, Cheng L, Li G, Wang Q, Yin X, Ma J, Chi L, Zhai X, Zhang Q, Zhang L, and Su L. CD123+AXL+DCs capture HIV-1 and delay HIV-1 transmission in humanized mice. 2018 (in preparation)

2.Cheng L, Wang Q, Li G, Banga R, Ma J, Yu H, Yasui F, Zhang Z, Pantaleo G, Perreau M, Zurawski S, Zurawski G, Levy Y, Su L. (2018). "TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs." J Clin Invest 128(10).

3.Zhao J, Cheng L, Wang H, Yu H, Tu B, Fu Q, Li G, Wang Q, Sun Y, Zhang X, Liu Z, Chen W, Zhang L, Su L, Zhang Z. (2018). "Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway." PLoS Pathog 14(1): e1006819.

4.Cheng L, Yu H, Li G, Li F, Ma J, Li J, Chi L, Zhang L, Su L. (2017). "Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infection." JCI Insight 2(12).

5.Cheng L, Ma J, Li J, Li D, Li G, Li F, Zhang Q, Yu H, Yasui F, Ye C, Tsao LC, Hu Z, Su L, Zhang L. (2017). "Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs." J Clin Invest 127(1): 269-279.

6.Ding J, Zhao J, Yang Z, Ma L, Mi Z, Wu Y, Guo J, Zhou J, Li X, Guo Y, Peng Z, Wei Tao, Yu H, Zhang L, Ge M, Cen S. (2017). "Microbial Natural Product Alternariol 5-O-Methyl Ether Inhibits HIV-1 Integration by Blocking Nuclear Import of the Pre-Integration Complex." Viruses 9(5): 105.

7.Mi Z, Ding J, Zhang Q, Zhao J, Ma L, Yu H, Liu Z, Shan G, Li X, Zhou J, Wei T, Zhang L, Guo F, Liang C, Cen S. (2015). "A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2." Sci Rep 5: 18499.

8.Li G, Cheng M, Nunoya J, Cheng L, Guo H, Yu H, Liu YJ, Su L, Zhang L. (2014). “Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice.” PLoS Pathog 10(7): e1004291.

 

树突状细胞相关文章:

 

9.Yin X*, Yu H*, Jin X, Li J, Guo H, Shi Q, Yin Z, Xu Y, Wang X, Liu R, Wang S, Zhang L. (2017). "Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions." J Immunol 198(4): 1553-1564. (*, Co-first author)

10.Li J, Du Q, Hu R, Wang Y, Yin X, Yu H, Du P, Plumas J, Chaperot L, Liu YJ, Zhang L. (2016). "Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production." Protein Cell 7(4): 291-294.

11.Yu H*, Zhang P*, Yin X, Yin Z, Shi Q, Cui Y, Liu G. Wang S, Piccaluga P. P, Jiang T, Zhang L. (2015). "Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset. " Protein Cell 6(4): 297-306. (*, Co-first author)

12.Ma J*, Yu H*, Yin X, Cheng M, Shi Q, Yin Z, Nie X, Shouli W, Zhang L. (2015). “E2-2, a novel immunohistochemical marker for both human and monkey plasmacytoid dendritic cells.” Biophysics reports:1 139-47. (*, Co-first author)

13.Cheng M, Zhang X, Yu H, Du P, Plumas J, Chaperot L, Su L, Zhang L. (2015). "Characterization of species-specific genes regulated by E2-2 in human plasmacytoid dendritic cells." Sci Rep 5: 10752.

14.Guo H, Zhang J, Zhang X, Wang Y, Yu H, Yin X, Li J, Du P, Plumas J, Chaperot L, Chen J, Su L, Liu Y, Zhang L. (2015). "SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7." J Immunol 194(10): 4737-4749.

 

其他的参与文章:

 

15.Ye L,Yu H, Li C, Hirsch M, Zhang L, Samulski R, Li W, Liu z. (2015). "Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice." PLoS One 10(6): e0130052.

16.Sun F, Yin Z, Yu HS, Shi QX, Zhao B, Zhang LG, Wang SL. (2015). "Cilostazol inhibits plasmacytoid dendritic cell activation and antigen presentation." J Geriatr Cardiol 12(4): 388-393.

17.Shi Q, Yin Z, Zhao B, Sun F, Yu H, Yin X, Zhang L, Wang S. (2015). "PGE2 Elevates IL-23 Production in Human Dendritic Cells via a cAMP Dependent Pathway." Mediators Inflamm 2015: 984690.

18.Lu Y, Yu H, Nie X, Li Y, Zhang L, Lu C. (2013). "Nonstructural proteins of Torque teno sus virus 2 from O2AUG: prediction to experimental validation." Virus Res 178(2): 272-280.

19.Hua J, Yu H, Dong W, Yang C, Gao Z, Lei A, Sun Y, Pan S, Wu Y, Dou Z. (2009). "Characterization of mesenchymal stem cells (MSCs) from human fetal lung: potential differentiation of germ cells." Tissue Cell 41(6): 448-455.